Health Inputs
  • Home
  • Health Tips
    • All
    • Amazing Health Facts
    • Diet & Nutrician
    • Exercise
    • Mental Health

    10 Tips For Good Health

    man

    10 Tips To Maintain Weight Loss

    Why Can’t I lose Weight? 7 Sneaky Causes Of Weight Loss Resistance

    Why Can’t I lose Weight? 7 Sneaky Causes Of Weight Loss Resistance

    chirp-shark-tank

    How to use the Self Massage Roller to reduce Post-Workout Pain

    depression-hope

    Too Depressed to Do Anything? Here is how to get Help

    muscle-building

    How Many Times Per Week To Train Each Muscle To Grow

    headache-migraine

    12 Foods That Can Trigger Migraine Pain

    chirp-wheel

    Wonders of Foam Roller for Back and Neck Pain

    massage-neck

    Self-Massage to Relax the Neck, Shoulders and Cervical

  • Home Remedies
    old-man sitting on stone

    Exercise for Seniors: 5 Tips to Help You Stay Active During the Coronavirus Pandemic

    Best-Diet-To-Lose-Weight

    11 Best Diet To Lose Weight – Eat As Much As You Want

    women

    How to Take Care of Health After 30s

    weight loss food

    15 High Protein Vegan Foods To Lose Weight

    dark-cicles-eyes

    10 Natural Home Remedies To Get Rid of Dark Circles Under Eyes

    honey

    17 Health Benefits of Honey & Its Uses

  • Beauty
    eucalyptus-bath

    Eucalyptus Bath To Relieve Stress, Headaches, and Skin Rejuvination

    wrinkles-under-eyes

    The secrets to ensure you don’t miss out on fabulous eyelashes

    dark-cicles-eyes

    Eye Bag Causes and Natural Remedies

    20 Tips on How to use Aloe Vera for Sunburn

    woman doing makeup

    New Years Eve Makeup Tips & Ideas

    ginger-root

    How To Make Homemade Ginger Oil

    makeup-tricks

    10 Myths About Makeup and Reality

    Tattoos

    5 Things You Need To Know About Removing Tattoos

    Tips and Tricks For Applying Lipstick

  • Nutrition
    chamomile tea

    6 Teas To Lower Cholesterol

    lemon

    10 Health Benefits of Lemon

    woman eating oats

    8 Scientifically Proven Benefits of Eating Oatmeal and Oats

    medicinal-herbs

    Chitrakadi Vati Uses and Amazing Benefits

    Yellow-kratom

    Buy Yellow Kratom: Know its Benefits, Strains and Effects

    barefoot-foot-socks-person

    Diabetic Socks: How to buy best ones?

    giloy

    10 Surprising Health Benefits of Giloy

    Ashwagandha

    Ashwagandha Advantages & Disadvantages

    fruits

    6 Health Benefits of Citrus Fruits

  • Alternative Therapies
    barefoot-foot-socks-person

    Diabetic Socks: How to buy best ones?

    massage

    Marma Therapy Benefits for Your body

    zumba

    8 Benefits of Zumba Dance for Weight Loss

    baby

    Safest Essential Oils For Babies

    Pranayama

    Pranayama : Types, Techniques and Benefits

    Shirodhara

    What Is Shirodhara Good For & Its Benefits

    Leech

    Hirudotherapy Medicinal Leech Therapy – Alternative Healing

    essential-oils

    Essential Oils For Hair

    Mortar-pestle

    Treatment With Metals In Ayurveda – Alt Therapy

No Result
View All Result
  • Home
  • Health Tips
    • All
    • Amazing Health Facts
    • Diet & Nutrician
    • Exercise
    • Mental Health

    10 Tips For Good Health

    man

    10 Tips To Maintain Weight Loss

    Why Can’t I lose Weight? 7 Sneaky Causes Of Weight Loss Resistance

    Why Can’t I lose Weight? 7 Sneaky Causes Of Weight Loss Resistance

    chirp-shark-tank

    How to use the Self Massage Roller to reduce Post-Workout Pain

    depression-hope

    Too Depressed to Do Anything? Here is how to get Help

    muscle-building

    How Many Times Per Week To Train Each Muscle To Grow

    headache-migraine

    12 Foods That Can Trigger Migraine Pain

    chirp-wheel

    Wonders of Foam Roller for Back and Neck Pain

    massage-neck

    Self-Massage to Relax the Neck, Shoulders and Cervical

  • Home Remedies
    old-man sitting on stone

    Exercise for Seniors: 5 Tips to Help You Stay Active During the Coronavirus Pandemic

    Best-Diet-To-Lose-Weight

    11 Best Diet To Lose Weight – Eat As Much As You Want

    women

    How to Take Care of Health After 30s

    weight loss food

    15 High Protein Vegan Foods To Lose Weight

    dark-cicles-eyes

    10 Natural Home Remedies To Get Rid of Dark Circles Under Eyes

    honey

    17 Health Benefits of Honey & Its Uses

  • Beauty
    eucalyptus-bath

    Eucalyptus Bath To Relieve Stress, Headaches, and Skin Rejuvination

    wrinkles-under-eyes

    The secrets to ensure you don’t miss out on fabulous eyelashes

    dark-cicles-eyes

    Eye Bag Causes and Natural Remedies

    20 Tips on How to use Aloe Vera for Sunburn

    woman doing makeup

    New Years Eve Makeup Tips & Ideas

    ginger-root

    How To Make Homemade Ginger Oil

    makeup-tricks

    10 Myths About Makeup and Reality

    Tattoos

    5 Things You Need To Know About Removing Tattoos

    Tips and Tricks For Applying Lipstick

  • Nutrition
    chamomile tea

    6 Teas To Lower Cholesterol

    lemon

    10 Health Benefits of Lemon

    woman eating oats

    8 Scientifically Proven Benefits of Eating Oatmeal and Oats

    medicinal-herbs

    Chitrakadi Vati Uses and Amazing Benefits

    Yellow-kratom

    Buy Yellow Kratom: Know its Benefits, Strains and Effects

    barefoot-foot-socks-person

    Diabetic Socks: How to buy best ones?

    giloy

    10 Surprising Health Benefits of Giloy

    Ashwagandha

    Ashwagandha Advantages & Disadvantages

    fruits

    6 Health Benefits of Citrus Fruits

  • Alternative Therapies
    barefoot-foot-socks-person

    Diabetic Socks: How to buy best ones?

    massage

    Marma Therapy Benefits for Your body

    zumba

    8 Benefits of Zumba Dance for Weight Loss

    baby

    Safest Essential Oils For Babies

    Pranayama

    Pranayama : Types, Techniques and Benefits

    Shirodhara

    What Is Shirodhara Good For & Its Benefits

    Leech

    Hirudotherapy Medicinal Leech Therapy – Alternative Healing

    essential-oils

    Essential Oils For Hair

    Mortar-pestle

    Treatment With Metals In Ayurveda – Alt Therapy

No Result
View All Result
HealthNews
No Result
View All Result
Home Daily Health Tips

How Long Does Cocaine Stay In Your System?

1.5k
VIEWS
Share on FacebookShare on Twitter

What is cocaine?

Cocaine, originally from coca leaves or Erythroxylon coca, and is a highly addictive, psychoactive, stimulant substance.[1] Over 100 years ago, a purified chemical named “cocaine hydrochloride” was isolated from the plant. Research has shown cocaine is a very addictive substance that can alter brain function and structure after multiple uses. It is now considered as having a powerful potential for abuse and classified as a Schedule II drug.[2]

cocaine-addiction

What does cocaine do to your body?

When in the body’s system, cocaine disrupts the brain’s “mesolimbic dopamine system” or its reward pathway. Naturally stimulated by outside reinforcement such as food or sex, this reward pathway also regulates motivation and emotions.[3] When an individual abuses the drug, the normal communication process between neurons and dopamine receptors is disrupted. Cocaine, for example, is found to block the transport of dopamine to neighboring neurons.[4] The result is the temporary sensation of euphoria commonly experienced right after taking the drug.

Effects of long-term use

The use of cocaine long-term has found to have lasting, if not permanent, changes in the brain. The drug has an immense impact on the brain’s pathways that respond to stress. As a result, the stress-related disorders that arise can contribute to cocaine relapse and cocaine use disorders. Research has shown that the brain’s ability to relay information about stress and drug use to other parts of the brain often overlap and get confounded. This confusion in the brain’s transmitters results in one’s likelihood of seeking out the drug in response to stress, therefore raising or reintroducing the level and amounts of drug intakes, and affecting the stress circuits and levels of stress in the body.[5]

Chronic cocaine use affects other areas of the brain such as the orbitofrontal cortex (OFC), the area with connections in the brain’s decision-making, impulsivity, self-insight, and memory.[6]

Does how cocaine is ingested affect how long it stays in the body?

The method of ingesting cocaine affects how quickly the drug reaches the brain, but it does not alter how long cocaine stays in the individual’s system. Once in the system, cocaine will show up in urine 3 to 6 hours after the last use.[7] The half-life of cocaine is about one hour, which means it takes about 60 minutes for the body to eliminate half of the drug from the bloodstream. It is important to note that long-term use can lead to longer elimination times, leading to certain tests being able to detect cocaine in the system for a longer period of time.[8]

Cocaine use & drug testing

Detection timeframes vary depending on the type of test initiated. Cocaine is metabolized by enzymes in the blood and liver, this process happens so rapidly that it is not detectable in most screening tests. The main metabolite present with cocaine in urine is benzoylecgonine, which can be detected in the urine for up to 4 days.[9] During drug testing, benzoylecgonine is the main metabolite searched because it has a urine concentration of 50 to 100 times higher than cocaine.

After the last use, cocaine metabolites can be detected in a saliva or blood test for up to 2 days.[10] Cocaine metabolites can be detected in the system after its last use with a saliva test from 24 to 48 hours.

After the last use, the drugs can be detected in a urine test from 1 to 4 days, or up to 2 weeks with frequent users.[11]

Cocaine or its metabolites can be detected in a hair sample from months to years from last use.[12] Drinking alcohol or caffeine while taking the drug slows its elimination from the body.[13] An important note – there are other factors that can influence how long cocaine stays in somebody’s system, such as their weight, metabolism, hydration levels, kidney or liver impairment, the dose, and frequency of use. The more cocaine an individual uses at a time, the longer the benzoylecgonine metabolite remains in the system and can be detected.[14] In addition to the frequency and volume of cocaine intake, the level of purity the drug itself is at when consumed also affects how quickly the body can eliminate benzoylecgonine from the system.

Sources & Resources

  • [1]  Withdrawal Info. Cocaine Addiction & Withdrawal.
  • [2] Drent M, Wijnen P, Bast A. Interstitial lung damage due to cocaine abuse: pathogenesis, pharmacogenomics and therapy. Curr Med Chem. 2012;19(33):5607-5611.
  • [3] Baik J-H. Dopamine signaling in reward-related behaviors. Front Neural Circuits. 2013;7.
  • [4] Johnston L, O’Malley P, Miech R, Bachman J, Schulenberg J. Monitoring the Future National Survey Results on Drug Use: 1975-2015: Overview: Key Findings on Adolescent Drug Use. Ann Arbor, MI: Institute for Social Research, The University of Michigan; 2015.
  • [5] Mantsch JR, Vranjkovic O, Twining RC, Gasser PJ, McReynolds JR, Blacktop JM. Neurobiological mechanisms that contribute to stress-related cocaine use. Neuropharmacology. 2014;76, Part B:383-394.
  • [6] Lucantonio F, Stalnaker TA, Shaham Y, Niv Y, Schoenbaum G. The impact of orbitofrontal dysfunction on cocaine addiction. Nat Neurosci. 2012;15(3):358-366.
  • [7] The University of Arizona MethOIDE. Cocaine: Pharmacology.
  • [8] Australian Government Department of Health. (2004). Pharmacology of cocaine.
  • [9] Redwood Toxicology Laboratory. Cocaine Drug Information.
  • [10] University of Rochester Medical Center. Cocaine Screen.
  • [11] Moeller, K., Kissack, J., Atayee, R., and Lee, K. (2017). Clinical Interpretation of Urine Drug Tests: What Clinicians Need to Know About Urine Drug Screens. Mayo Clinic Proceedings.
  • [12] Warner, T. D., Behnke, M., Eyler, F. D., and Szabo, N. J. (2011). Early adolescent cocaine use as determined by hair analysis in a prenatal cocaine exposure cohort. Neurotoxicology and teratology, 33(1), 88-99.
  • [13] Shimomura E, Jackson G, Paul B. Cocaine, crack cocaine, and ethanol: A deadly mix. In: Dasgupta A, ed. Critical Issues in Alcohol and Drugs of Abuse Testing, (Second Edition). Academic Press; 2019: pages 215-224.
  • [14] Huestis MA, Darwin WD, Shimomura E, et al. Cocaine and metabolites urinary excretion after controlled smoked administration. J Anal Toxicol. 2007;31(8):462-8.

Tags: drug abusedrugs
Previous Post

Prostate Cancer: Watchful Waiting vs. Active Surveillance

Next Post

10 Surprising Health Benefits of Giloy

Next Post
giloy

10 Surprising Health Benefits of Giloy

More Articles

  • 10 Tips For Good Health
  • How To Treat Sinus Infection At Home – 10 Ways
  • Eucalyptus Bath To Relieve Stress, Headaches, and Skin Rejuvination
  • 10 Tips To Maintain Weight Loss
  • 6 Teas To Lower Cholesterol
  • Why Can’t I lose Weight? 7 Sneaky Causes Of Weight Loss Resistance
  • How to use the Self Massage Roller to reduce Post-Workout Pain
  • Hair Building Fibers Are they good They’re for you
  • 10 Health Benefits of Lemon
  • Couples Therapy: What is it and when to start?

Tags

Acne Allergy alternative medicine angola Ayurvedic Remedies Cancer Children coronavirus dental care tips dentist diabetes diabetic care diabetic products diabetic socks drug abuse drugs eyes eye tips green tea hair Headache herbal tea herbs kratom Marijuana men mental health misconceptions natural cough remedies occult oral health Parkinson Disease pregnancy sinus skin Stress supplements teeth care vitamins weight gain weight loss women yellow kratom
logo

Categories

  • Alternative Therapies
  • Amazing Health Facts
  • Beauty Tips
  • Daily Health Tips
  • Diet & Nutrician
  • Exercise
  • Featured
  • Health Benefits
  • Health Products
  • Medical
  • Mental Health
  • Natural Home Remedies
  • News
  • Parenting Tips
  • Psychology
  • Relationship
  • Self Improvement

Tags

Acne Allergy alternative medicine angola Ayurvedic Remedies Cancer Children coronavirus dental care tips dentist diabetes diabetic care diabetic products diabetic socks drug abuse drugs eyes eye tips green tea hair Headache herbal tea herbs kratom Marijuana men mental health misconceptions natural cough remedies occult oral health Parkinson Disease pregnancy sinus skin Stress supplements teeth care vitamins weight gain weight loss women yellow kratom
  • Home
  • News
  • Disclaimer
  • Privacy Policy
  • Contact Us

© 2015 - 2023 Healthinputs.com | Web Design & SEO Services by Seohawk

No Result
View All Result
  • Home
  • Health Tips
  • Home Remedies
  • Beauty
  • Nutrition
  • Alternative Therapies

© 2015 - 2023 Healthinputs.com | Web Design & SEO Services by Seohawk